RPA0104 Recombinant Human IL-4 Protein

产品规格

种属

Human

Expression System

E. coli

氨基酸序列

HKCDITLQEI IKTLNSLTEQ KTLCTELTVT DIFAASKNTT EKETFCRAAT VLRQFYSHHE KDTRCLGATA QQFHRHKQLI RFLKRLDRNL WGLAGLNSCP VKEANQSTLE NFLERLKTIM REKYSKCSS

分子量

14.9 kDa

分类

Recombinant

类型

Protein

纯度

>95% by SDS-PAGE

内毒素浓度

<0.1 ng/µg

活性

ED50 = 0.05 - 0.4 ng/mL; determined by the dose-dependent proliferation of human TF-1 cells.

偶联物

Unconjugated

形式

Liquid (1mg/ml)

纯化类型

sequential chromatography

内含物

no preservative

保存条件

4° C

产品详细信息

Carrier-Free

Reconstitution: Centrifuge the vial briefly, before opening to bring the contents to the bottom. Apportion the reconstituted protein into working aliquots and store at -20°C (not in a frost-free freezer). Avoid repeated freeze-thaw cycles.. Make any further dilutions of the reconstituted protein in low endotoxin medium or buffered solution with FCS or tissue culture grade BSA.

靶标信息

Interleukin-4 (IL-4) is a pleiotropic, immune-modulatory cytokine produced by activated T cells, and serves as a ligand for interleukin 4 receptor. IL-4 has been found to have the broadest range of actions. The interleukin 4 receptor also binds to IL13, which may contribute to many overlapping functions of this cytokine and IL13. STAT6, a signal transducer and activator of transcription, has been shown to play an important role in mediating the immune regulatory signal of IL-4. The IL-4 gene, IL-3, IL-5, IL-13, and CSF2 form a cytokine gene cluster on chromosome 5q. In particular, IL-4 is located in close proximity to IL13 on the chromosome. Further, the IL-4 gene, IL13 and IL5 are found to be coordinated by several long-range regulatory elements over a 120 kilobase range on the chromosome. IL-4 delta 2 is a known splice variant of IL-4.

仅用于科研。不用于诊断过程。